TAK1 inhibitor
Code | Size | Price |
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TAR-T67909-5mg | 5mg | £2,054.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T67909-50mg | 50mg | £4,070.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T67909-100mg | 100mg | £5,693.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Images
Documents
Further Information
Bioactivity:
TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively. TAK1 inhibitor showed good antibacterial activity with microphones ranging from 93.7 to 46.9ug/mL and from 7.8 to 5.8ug/mL.
CAS:
1326712-16-6
Molecular Weight:
466.94
Pathway:
DNA Damage/DNA Repair
Purity:
0.98
SMILES:
ClC=1C2=C(C=NC(N)=C2OC1C3=C4C(=CC=C3)N=NS4)C5=CN(N=C5)[C@@H]6CC[C@@H](O)CC6
Target:
Topoisomerase
References
Hornberger KR, et al. Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics. Bioorg Med Chem Lett. 2013;23(16):4511-4516.
Veerman JJN, et al. Discovery of 2,4-1H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. ACS Med Chem Lett. 2021;12(4):555-56