Sofnobrutinib
Code | Size | Price |
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TAR-T72865-5mg | 5mg | £1,091.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T72865-50mg | 50mg | £2,143.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T72865-100mg | 100mg | £2,801.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Images
Documents
Further Information
Bioactivity:
Sofnobrutinib (AS-0871) is an orally active and selective BTK inhibitor, with IC 50 s of 4.2 nM (activated BTK ) and 0.39 nM (unactivated BTK ), respectively. Sofnobrutinib also inhibits hERG with an IC 50 value of 24 uM. Sofnobrutinib has good metabolic stability and bioavailability. Sofnobrutinib results poor passive cutaneous anaphylaxis reaction, as well as exerting anti-inflammatory effects in collagen-induced arthritis model in mice .
CAS:
1646608-10-7
Molecular Weight:
498.51
Purity:
0.98
SMILES:
O=C1C=2C(F)=CC(=CC2C=CN1C3=CC=CC(C=4N=C(N=C(N4)NC=5C=NN(C5)C)N)=C3CO)C6CC6