NRX-0492
Code | Size | Price |
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TAR-T75133-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T75133-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
NRX-0492 is an orally active and potent degrader of BTK . NRX-0492 catalyzes ubiquitylation and proteasomal degradation of BTK with DC 50 ≤0.2 nM and DC 90 ≤0.5 nM, respectively. NRX-0492 inhibits B-cell receptor (BCR)-mediated signaling, transcriptional programs, and chemokine secretion. Moreover, NRX-0492 also links a noncovalent BTK-binding domain to Cereblon . Cereblon is an adaptor protein of the E3 ubiquitin ligase complex [1] .
CAS:
2416130-57-7
Molecular Weight:
817.94
Purity:
0.98