Capillarisin
| Code | Size | Price |
|---|
| TAR-TN3587-5mg | 5mg | £577.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-TN3587-1mL | 1 mL * 10 mM (in DMSO) | £593.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with G0/G1-phase cell cycle arrest and loss in mitochondrial membrane potential.Capillarisin has anti-inflammatory activity, can inhibit LPS-induced inflammation by blocking TLR4-mediated NF-κB and MAPKs activation in BV2 microglia. Capillarisin possesses promising anti-hyperalgesic and anti-allodynic effects through the inhibition of various inflammatory pain signaling.
CAS:
56365-38-9
Formula:
C16H12O7
Molecular Weight:
316.26
Pathway:
Cell Cycle/Checkpoint|GPCR/G Protein|JAK/STAT signaling|Stem Cells|Apoptosis|Neuroscience|Tyrosine Kinase/Adaptors|DNA Damage/DNA Repair|MAPK|Proteases/Proteasome|Angiogenesis|Immunology/Inflammation|NF-κb
Purity:
0.98
SMILES:
O=C1C=C(OC2=CC=C(O)C=C2)OC3=CC(O)=C(OC)C(O)=C13
Target:
TNF|STAT|Prostaglandin Receptor|JNK|NF-κB|MAPK|BCL|TLR|COX|DNA/RNA Synthesis|NOS|IL Receptor|ERK|VEGFR|MMP