Poseltinib
| Code | Size | Price |
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| TAR-T4413-10mg | 10mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| TAR-T4413-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Poseltinib, an orally active, selective and irreversible inhibitor of Bruton?s tyrosine kinase (BTK) ( IC 50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively. Poseltinib can covalently bind to the active site (cysteine 481 residue) of BTK, and reveales potent inhibition of B cell receptor ( BCR ), Fc receptor ( FcR ), Toll-like receptor ( TLR ) mediated signaling [1].
CAS:
1353552-97-2
Molecular Weight:
470.52
Purity:
0.98
SMILES:
O=C(C=C)NC=1C=CC=C(OC2=NC(=NC=3C=COC23)NC4=CC=C(C=C4)N5CCN(C)CC5)C1