Simmiparib
| Code | Size | Price |
|---|
| TAR-T63228-50mg | 50mg | £1,203.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T63228-100mg | 100mg | £1,854.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Simmiparib is an orally active and potent inhibitor of PARP1 and PARP2 with IC50 values of 1.75 nM and 0.22 nM, respectively, and exhibits significant anticancer effects in both cellular and nude mouse transplantation tumor models. simmiparib inhibits PARP1/2 more potently than its parent compound Olaparib. Simmiparib induced the accumulation of DNA double-strand breaks (DSBs) and G2/M blockage in homologous recombination repair (HR) deficient cells, and induced apoptosis.
CAS:
1551355-46-4
Molecular Weight:
486.431
Purity:
0.98
SMILES:
CC1CN(Cc2nnc(n12)C(F)(F)F)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F