TargetMol

DVD-445

Product Code:
 
TAR-T11130
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T11130-100mg100mgEnquire
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Further Information

Bioactivity:
Dvd-445 has good anti-cancer effect.Dvd-445 is an effective peptide covalent thioredoxin reductase 1 (TrxR1) inhibitor with IC50 value of 0.60 mol/L M.
CAS:
2375846-41-4
Formula:
C25H28F2N2O4
Molecular Weight:
458.5
Purity:
0.98
SMILES:
C(N(CCOC(/C=C/C(=O)C1=CC=C(F)C=C1)=O)C)(C(NC(C)(C)C)=O)C2=CC=C(F)C=C2

References

Jovanovi? M, et al. Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy. Eur J Med Chem. 2019 Aug 1;181:111580.