TargetMol

Ophiobolin A

Product Code:
 
TAR-T16397
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Ophiobolin A is a fungal metabolite and a phytotoxin and is an effective and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase (IC50: 9 uM). Ophiobolin A also has antimicrobial and anticancer activity.
CAS:
06/05/4611
Formula:
C25H36O4
Molecular Weight:
400.559
Purity:
0.98
SMILES:
[H][C@]12[#6][C@@]3([#6])[#6]-[#6][C@@]4([#8]-[#6@H](-[#6]-[#6@@H]4-[#6])\[#6]=[#6](\[#6])-[#6])[C@]3([H])[#6]-[#6]=[#6](-[#6]=O)[C@@]1([H])[#6](=O)-[#6][C@@]2([#6])[#8] |w:20.21|

References

Leung PC, et al. Ophiobolin A. A natural product inhibitor of calmodulin. J Biol Chem. 1984 Mar 10;259(5):2742-7