Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine, a cleavable PEG ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker, specifically Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane, widely used in the synthesis of PROTACs[1].
CAS:
175724-30-8
Formula:
C25H47NO9
Molecular Weight:
505.64
Purity:
0.98
SMILES:
O=C(OC(C)(C)C)CCOCC(N)(COCCC(=O)OC(C)(C)C)COCCC(=O)OC(C)(C)C
References
Kostiainen MA, et al. Optically degradable dendrons for temporary adhesion of proteins to DNA. Chemistry. 2010 Jun 18;16(23):6912-8.