K-Ras ligand-Linker Conjugate 3
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| TAR-T18056-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| TAR-T18056-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound that consists of a ligand for K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential in the synthesis of PROTAC K-Ras Degrader-1, a potent PROTAC K-Ras degrader that demonstrates a degradation efficacy of ≥70% in SW1573 cells[1].
CAS:
2378261-87-9
Molecular Weight:
944.15
Purity:
0.98
SMILES:
O(C[C@@H]1C[C@@H](OCCOCCOCCOCCOS(=O)(=O)C2=CC=C(C)C=C2)CN1C)C3=NC(=C4C(CN(CC4)C=5C6=C(C=CC5)C=CC=C6)=N3)N7C[C@H](CC#N)N(C(OC(C)(C)C)=O)CC7
References
Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2.