TargetMol

PROTAC ER Degrader-3

Product Code:
 
TAR-T18607
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
PROTAC ER Degrader-3, an intermediate for the synthesis of PAC, is a compound derived from patent WO2017201449A1, specifically compound LP2. PAC serves as the linker for ADCs and PROTACs that are conjugated to an antibody. Notably, when PAC is conjugated to an antibody, it exhibits enhanced degradation of estrogen receptor-alpha (ERα) compared to PROTAC alone [1].
CAS:
2158322-29-1
Molecular Weight:
1220.434
Purity:
0.98
SMILES:
CCC(=C(c1ccc(O)cc1)c1ccc(OCCN(C)C(=O)COCCOCCNC(=O)c2ccc(cc2)C(=O)N2[C@@H](C)[C@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(=O)N(Cc3c(OC)ccc4ccccc34)c3ccc(cc23)C#N)cc1)c1ccccc1 |w:3.11|

References

Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.