TargetMol

Latrunculin B

Product Code:
 
TAR-T20636
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Latrunculin B causes changes in actin organization and cell shape. It sequesters G-actin and prevents F-actin assembly. It binds monomeric actin and blocks actin polymerization both in vitro and in cells with the Kd of 60 nM. Latrunculin B is extracted from the Red Sea sponge Latrunculia magnifica.
CAS:
76343-94-7
Molecular Weight:
395.51
Purity:
0.98
SMILES:
O[C@]1([C@]2(NC(=O)SC2)[H])C[C@]3(C[C@](O1)(CC[C@H](C)/C=C\CC\C(\C)=C\C(=O)O3)[H])[H]

References

Thomasy SM, Wood JA, Kass PH, Murphy CJ, Russell P. Substratum stiffness and latrunculin B regulate matrix gene and protein expression in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2012 Feb 23;53(2):952-8. doi: 10.1167/iovs.11-8526. Print 2012 Feb. PubMed PMID: 22247475; PubMed Central PMCID: PMC3317432. Thomasy SM, Morgan JT, Wood JA, Murphy CJ, Russell P. Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells. Exp Eye Res. 2013 Aug;113:66-73. doi: 10.1016/j.exer.2013.05.014. Epub 2013 May 29. PubMed PMID: 23727052; PubMed Central PMCID: PMC3737383. Wakatsuki T, Schwab B, Thompson NC, Elson EL. Effects of cytochalasin D and latrunculin B on mechanical properties of cells. J Cell Sci. 2001 Mar;114(Pt 5):1025-36. PubMed PMID: 11181185. Lu YY, Lin YK, Wen ZH, Chen YC, Chen SA, Chen YJ. Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Clin Sci (Lond). 2016 May;130(9):721-32. doi: 10.1042/CS20150593. Epub 2016 Feb 2. PubMed PMID: 26839418.