Diacetolol
| Code | Size | Price |
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| TAR-T21010-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T21010-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Diacetolol is the major metabolite of acebutolol, a selective beta blockers used to treat hypertension, angina pectoris and arrhythmia.
CAS:
22568-64-5
Formula:
C16H24N2O4
Molecular Weight:
308.3728
Purity:
0.98
SMILES:
CC(C)NCC(O)COc1ccc(NC(C)=O)cc1C(C)=O
References
Muta K, Fukami T, Nakajima M. A proposed mechanism for the adverse effects of acebutolol: CES2 and CYP2C19-mediated metabolism and antinuclear antibody production. Biochem Pharmacol. 2015 Dec 15;98(4):659-70. doi: 10.1016/j.bcp.2015.09.016. Epub 2015 Sep 25. PubMed PMID: 26408002.
Coombs TJ, Coulson CJ, Smith VJ. Blood plasma binding of acebutolol and diacetolol in man. Br J Clin Pharmacol. 1980 Apr;9(4):395-7. PubMed PMID: 7378256; PubMed Central PMCID: PMC1429991.
Ohashi K, Warrington SJ, Kaye CM, Houghton GW, Dennis M, Templeton R, Turner P. Observations on the clinical pharmacology and plasma concentrations of diacetolol, the major human metabolite of acebutolol. Br J Clin Pharmacol. 1981 Oct;12(4):561-5. PubMed PMID: 7295489; PubMed Central PMCID: PMC1401897.
Sankey MG, Gulaid A, Kaye CM. Preliminary study of the disposition in man of acebutolol and its metabolite, diacetolol, using a new stereoselective hplc method. J Pharm Pharmacol. 1984 Apr;36(4):276-7. PubMed PMID: 6144783.