Deutetrabenazine metabolite M4
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| TAR-T23983-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Deutetrabenazine metabolite M4 is believed to be related to its effect as a reversible depletion of monoamines from nerve terminals. The major circulating metabolites of Deutetrabenazine, are reversible inhibitors of VMAT2, resulting in decreased uptake of monoamines into synaptic vesicles and depletion of monoamine stores.
CAS:
1688661-95-1
Molecular Weight:
339.46
Purity:
0.98
SMILES:
O(C([2H])([2H])[2H])C=1C=C2[C@]3(N(C[C@H](CC(C)(C)O)C(=O)C3)CCC2=CC1OC([2H])([2H])[2H])[H]
References
Geschwind MD, Paras N. Deutetrabenazine for Treatment of Chorea in Huntington Disease. JAMA. 2016 Jul 5;316(1):33-5. doi: 10.1001/jama.2016.8011. PubMed PMID: 27380339.
Jankovic J, Jimenez-Shahed J, Budman C, Coffey B, Murphy T, Shprecher D, Stamler D. Deutetrabenazine in Tics Associated with Tourette Syndrome. Tremor Other Hyperkinet Mov (N Y). 2016 Nov 7;6:422. eCollection 2016. PubMed PMID: 27917309; PubMed Central PMCID: PMC5133390.
Reilmann R. Deutetrabenazine-Not a Revolution but Welcome Evolution for Treating Chorea in Huntington Disease. JAMA Neurol. 2016 Dec 1;73(12):1404-1406. doi: 10.1001/jamaneurol.2016.3916. PubMed PMID: 27749952.
Huntington Study Group, Frank S, Testa CM,et al. Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial. JAMA. 2016 Jul 5;316(1):40-50. doi: 10.1001/jama.2016.8655. PubMed PMID: 27380342.