L 659874
| Code | Size | Price |
|---|
| TAR-T24313-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24313-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
L 659874 is a cyclic hexapeptide. It is also a tachykinin antagonist.
CAS:
125989-15-3
Molecular Weight:
821.98
Purity:
0.98
SMILES:
C([C@@H](C(N[C@@H](CC1=CC=CC=C1)C(NCC(N)=O)=O)=O)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC(C)=O)=O)CCSC)=O)CCC(N)=O)=O)C=2C=3C(NC2)=CC=CC3
References
Hall JM, Flowers JM, Morton IK. A pharmacological study of NK1 and NK2 tachykinin receptor characteristics in the rat isolated urinary bladder. Br J Pharmacol. 1992 Nov;107(3):777-84. PubMed PMID: 1282072; PubMed Central PMCID: PMC1907736.
Fleetwood-Walker SM, Parker RM, Munro FE, Young MR, Hope PJ, Mitchell R. Evidence for a role of tachykinin NK2 receptors in mediating brief nociceptive inputs to rat dorsal horn (laminae III-V) neurons. Eur J Pharmacol. 1993 Sep 28;242(2):173-81. PubMed PMID: 8253113.
Fan TP, Hu DE, Guard S, Gresham GA, Watling KJ. Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK1 or interleukin-1 receptor antagonists. Br J Pharmacol. 1993 Sep;110(1):43-9. PubMed PMID: 7693287; PubMed Central PMCID: PMC2176009.
Munro FE, Fleetwood-Walker SM, Parker RM, Mitchell R. The effects of neurokinin receptor antagonists on mustard oil-evoked activation of rat dorsal horn neurons. Neuropeptides. 1993 Nov;25(5):299-305. PubMed PMID: 8115032.