L 687781
| Code | Size | Price |
|---|
| TAR-T24335-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24335-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
L 687781 is a natural product that is a member of the papulacandin family. L 687781 is also a 1,3-beta-glucan synthesis inhibitor.
CAS:
130304-58-4
Molecular Weight:
903.028
Purity:
0.98
SMILES:
CCC(C)CCC=CC=C(C)C(O)CC=CC=CC(=O)OC1C(O)C2(OCc3cc(O)cc(O)c23)OC(CO)C1OC1OC(COC(=O)C=CC=CCCC(O)CC)C(O)C(O)C1O |w:17.17,15.15,8.7,6.5,48.50,50.52|
References
Kurtz MB, Abruzzo G, Flattery A, Bartizal K, Marrinan JA, Li W, Milligan J, Nollstadt K, Douglas CM. Characterization of echinocandin-resistant mutants of Candida albicans: genetic, biochemical, and virulence studies. Infect Immun. 1996 Aug;64(8):3244-51. PubMed PMID: 8757860; PubMed Central PMCID: PMC174214.
Bartizal K, Abruzzo G, Trainor C, Krupa D, Nollstadt K, Schmatz D, Schwartz R, Hammond M, Balkovec J, Vanmiddlesworth F. In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin. Antimicrob Agents Chemother. 1992 Aug;36(8):1648-57. PubMed PMID: 1416847; PubMed Central PMCID: PMC192025.
VanMiddlesworth F, Omstead MN, Schmatz D, Bartizal K, Fromtling R, Bills G, Nollstadt K, Honeycutt S, Zweerink M, Garrity G, et al. L-687,781, a new member of the papulacandin family of beta-1,3-D-glucan synthesis inhibitors. I. Fermentation, isolation, and biological activity. J Antibiot (Tokyo). 1991 Jan;44(1):45-51. PubMed PMID: 2001985.
Aoki M, Andoh T, Ueki T, Masuyoshi S, Sugawara K, Oki T. BU-4794F, a new beta-1,3-glucan synthase inhibitor. J Antibiot (Tokyo). 1993 Jun;46(6):952-60. PubMed PMID: 8344877.