Spiraprilat
| Code | Size | Price |
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| TAR-T24820-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24820-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Spiraprilat is an ACE inhibitor. It also is an active metabolite of spirapril.
CAS:
83602-05-5
Molecular Weight:
438.56
Purity:
0.98
SMILES:
C([C@@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C)(=O)N2CC3(C[C@H]2C(O)=O)SCCS3
References
Sch?rer M, Erb K, Junge K, Sch?fer HF, Schulz HU, Amschler S, Krupp S, Hermann R. Drug interaction of spirapril hydrochloride monohydrate and hydrochlorothiazide. A clinical study to compare the pharmacokinetics after administration of spirapril hydrochloride monohydrate tablets, hydrochlorothiazide tablets and fixed combination bi-layer tablets. Arzneimittelforschung. 2003;53(6):414-9. PubMed PMID: 12872612.
Sramko M, Smiesko M, Remko M. Accurate aqueous proton dissociation constants calculations for selected angiotensin-converting enzyme inhibitors. J Biomol Struct Dyn. 2008 Jun;25(6):599-608. PubMed PMID: 18399693.
Sch?rer M, Amschler S, Schulz HU, Sch?fer HF. Simultaneous determination of spirapril and spiraprilat in plasma by capillary gas chromatography-mass spectrometry. Arzneimittelforschung. 2003;53(5):307-13. PubMed PMID: 12854357.
Hayduk K, Kraul H. Efficacy and safety of spirapril in mild-to-moderate hypertension. J Cardiovasc Pharmacol. 1999 Aug;34 Suppl 1:S19-23. Review. PubMed PMID: 10499560.