AK-295
| Code | Size | Price |
|---|
| TAR-T25011-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25011-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
AK 295, also known as CX 295, is a dipeptide inhibitor of alpha-ketoamide calpain.
CAS:
160399-35-9
Molecular Weight:
504.62
Purity:
0.98
SMILES:
[C@H](C(NC(C(C(NCCCN1CCOCC1)=O)=O)CC)=O)(NC(OCC2=CC=CC=C2)=O)CC(C)C
References
Blomgren K, Zhu C, Wang X, Karlsson JO, Leverin AL, Bahr BA, Mallard C, Hagberg H. Synergistic activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis"? J Biol Chem. 2001 Mar 30;276(13):10191-8. Epub 2000 Dec 21. PubMed PMID: 11124942.
Colak A, Kaya M, Karao?lan A, Sa?manligil A, Akdemir O, Sahan E, Celik O. Calpain inhibitor AK 295 inhibits calpain-induced apoptosis and improves neurologic function after traumatic spinal cord injury in rats. Neurocirugia (Astur). 2009 Jun;20(3):245-54. PubMed PMID: 19575128.
Wang MS, Davis AA, Culver DG, Wang Q, Powers JC, Glass JD. Calpain inhibition protects against Taxol-induced sensory neuropathy. Brain. 2004 Mar;127(Pt 3):671-9. Epub 2004 Feb 4. PubMed PMID: 14761904.
Caba E, Brown QB, Kawasaki B, Bahr BA. Peptidyl alpha-keto amide inhibitor of calpain blocks excitotoxic damage without affecting signal transduction events. J Neurosci Res. 2002 Mar 15;67(6):787-94. PubMed PMID: 11891793.