Allotrap
| Code | Size | Price |
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| TAR-T25051-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| TAR-T25051-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Allotrap is a small synthetic peptide derived from the alpha1 helix of the heavy chain of HLA class I proteins. It suppresses human T cell responses in vitro. It prolongs allograft survival in rats and mice.
CAS:
151232-75-6
Molecular Weight:
1263.41
Purity:
0.98
SMILES:
[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC1=CC=C(O)C=C1)C(O)=O)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CC(N)=O)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CCC(O)=O)=O)CO)=O)CC(C)C)=O)CCCNC(=N)N
References
Buelow R, Veyron P, Clayberger C, Pouletty P, Touraine JL. Prolongation of skin allograft survival in mice following administration of ALLOTRAP. Transplantation. 1995 Feb 27;59(4):455-60. PubMed PMID: 7878745.
Tice DG, Bruch D, Buelow R, Squiers EC. Survival of rat small bowel allografts treated with allotrap 07R. J Surg Res. 1997 Sep;72(1):78-83. PubMed PMID: 9344717.
Iyer S, Kontoyiannis D, Chevrier D, Woo J, Mori N, Cornejo M, Kollias G, Buelow R. Inhibition of tumor necrosis factor mRNA translation by a rationally designed immunomodulatory peptide. J Biol Chem. 2000 Jun 2;275(22):17051-7. PubMed PMID: 10748117.
Oberyszyn TM, Robertson FM, Tober KL, Ross MS, Parrett ML, Wilgus TA, Iyer S, Woo J, Buelow R. Inhibition of cutaneous UV light-induced tumor necrosis factor-alpha protein production by Allotrap 1258, a novel immunomodulatory peptide. Photochem Photobiol. 2001 Feb;73(2):184-90. PubMed PMID: 11272733.