Biphalin
| Code | Size | Price |
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| TAR-T25155-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25155-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Biphalin is a synthetic opioid octapeptide with a palindromic sequence that has high analgesic activity. Biphalin shows a potent affinity for u and δ-opioid receptors and a significant to κ-receptor.
CAS:
83916-01-2
Molecular Weight:
909
Purity:
0.98
SMILES:
[C@H](CC1=CC=CC=C1)(C(NNC([C@H](CC2=CC=CC=C2)NC(CNC([C@H](NC([C@H](CC3=CC=C(O)C=C3)N)=O)C)=O)=O)=O)=O)NC(CNC([C@H](NC([C@H](CC4=CC=C(O)C=C4)N)=O)C)=O)=O
References
Fr?czak O, Lasota A, Kosson P, Le?niak A, Muchowska A, Lipkowski AW, Olma A. Biphalin analogs containing ?(3)-homo-amino acids at the 4,4' positions: Synthesis and opioid activity profiles. Peptides. 2015 Apr;66:13-8. doi: 10.1016/j.peptides.2015.02.004. Epub 2015 Feb 20. PubMed PMID: 25708417.
B?dzy?ska B, Lipkowski AW, Sadowski J. An antihypertensive opioid: Biphalin, a synthetic non-addictive enkephalin analog decreases blood pressure in spontaneously hypertensive rats. Pharmacol Rep. 2016 Feb;68(1):51-5. doi: 10.1016/j.pharep.2015.06.006. Epub 2015 Jun 26. PubMed PMID: 26721351.
Sobczak M, Pilarczyk A, Jonakowski M, Jarmu? A, Sa?aga M, Lipkowski AW, Fichna J. Anti-inflammatory and antinociceptive action of the dimeric enkephalin peptide biphalin in the mouse model of colitis: new potential treatment of abdominal pain associated with inflammatory bowel diseases. Peptides. 2014 Oct;60:102-6. doi: 10.1016/j.peptides.2014.08.005. Epub 2014 Aug 20. PubMed PMID: 25151037.
Zieli?ska M, Jarmu? A, Sa?aga M, Lipkowski AW, Fichna J. Mixed MOP/DOP agonist biphalin elicits anti-transit effect in mouse models mimicking diarrhea-predominant irritable bowel syndrome symptoms. Pharmacol Rep. 2016 Feb;68(1):32-6. doi: 10.1016/j.pharep.2015.06.001. Epub 2015 Jun 12. PubMed PMID: 26721348.