H 142
| Code | Size | Price |
|---|
| TAR-T25479-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| TAR-T25479-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
H 142 is a human renin decapeptide inhibitor.
CAS:
85139-12-4
Molecular Weight:
1210.47
Purity:
0.98
SMILES:
C([C@H](CC1=CN=CN1)NC(=O)[C@@H]2CCCN2)(=O)N3[C@H](C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC5=CN=CN5)C(N[C@H](CN[C@H](C(N[C@H](C(N[C@@H](CC6=CN=CN6)C(N[C@@H](CCCCN)C(O)=O)=O)=O)[C@H](CC)C)=O)C(C)C)CC(C)C)=O)=O)=O)CCC3
References
Tree M, Atrash B, Donovan B, Gamble J, Hallett A, Hughes M, Jones DM, Leckie B, Lever AF, Morton JJ, et al. New inhibitors of human renin tested in vitro and in vivo in the anaesthetized baboon. J Hypertens. 1983 Dec;1(4):399-403. PubMed PMID: 6398331.
Hofbauer KG, M?nard J, Michel JB, Wood JM. Inhibition of renin in the primate Callithrix jacchus (common marmoset). Clin Exp Hypertens A. 1983;5(7-8):1237-47. PubMed PMID: 6196144.
Tree M, Szelke M, Leckie B, Atrash B, Donovan B, Hallett A, Jones DM, Lever AF, Morton JJ, Sueiras-Diaz J, et al. Renin inhibitors: their use in understanding the role of angiotensin II as a pressor hormone. J Cardiovasc Pharmacol. 1985;7 Suppl 4:S49-52. PubMed PMID: 2412013.
Webb DJ, Cumming AM, Leckie BJ, Lever AF, Morton JJ, Robertson JI, Szelke M, Donovan B. Reduction of blood pressure in man with H-142, a potent new renin inhibitor. Lancet. 1983 Dec 24-31;2(8365-66):1486-7. PubMed PMID: 6140568.