Hexaglutamate folate
| Code | Size | Price |
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| TAR-T25496-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25496-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Hexaglutamate folate is a naturally occurring form of folic acid. The bioavailability of dietary folate may be limited by the need for the glutamate moieties to be deconjugated before absorption. Folate deficiency in humans results in anemia, neural tube defects, and, possibly, chronic diseases such as cardiovascular disease, colon cancer, and neurocognitive dysfunction.
CAS:
35409-55-3
Molecular Weight:
1086.97
Purity:
0.98
SMILES:
O=C1C=2C(NC=C(CNC3=CC=C(C(N[C@@H](CCC(N[C@@H](CCC(N[C@@H](CCC(N[C@@H](CCC(N[C@@H](CCC(N[C@@H](CCC(O)=O)C(O)=O)=O)C(O)=O)=O)C(O)=O)=O)C(O)=O)=O)C(O)=O)=O)C(O)=O)=O)C=C3)N2)=NC(N)=N1
References
Nelson EW, Crick WF, Cerda JJ, Wilder BJ, Streiff RR. The effect of diphenylhydantoin (phenytoin) on the sequential stages of intestinal folate absorption. Drug Nutr Interact. 1983;2(1):47-56. PubMed PMID: 6689591.
Melse-Boonstra A, Verhoef P, West CE, van Rhijn JA, van Breemen RB, Lasaroms JJ, Garbis SD, Katan MB, Kok FJ. A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses. Am J Clin Nutr. 2006 Nov;84(5):1128-33. PubMed PMID: 17093166.
Wong GK, Rao AV. Effects of dietary protein on the subacute toxicity of butylated hydroxytoluene (BHT) in rats. Drug Nutr Interact. 1983;2(1):57-68. PubMed PMID: 6678747.
Wei MM, Bailey LB, Toth JP, Gregory JF 3rd. Bioavailability for humans of deuterium-labeled monoglutamyl and polyglutamyl folates is affected by selected foods. J Nutr. 1996 Dec;126(12):3100-8. PubMed PMID: 9001380.