Ici 200880
| Code | Size | Price |
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| TAR-T25521-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| TAR-T25521-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Ici 200880 is a human neutrophil elastase synthetic peptide inhibitor.
CAS:
105080-50-0
Molecular Weight:
687.13
Purity:
0.98
SMILES:
C([C@@H](NC(=O)C1=CC=C(C(NS(=O)(=O)C2=CC=C(Cl)C=C2)=O)C=C1)C(C)C)(=O)N3[C@H](C(NC(C(C(F)(F)F)=O)C(C)C)=O)CCC3
References
Mehta JL, Nichols WW, Nicolini FA, Hendricks J, Donnelly WH, Saldeen TG. Neutrophil elastase inhibitor ICI 200,880 protects against attenuation of coronary flow reserve and myocardial dysfunction following temporary coronary artery occlusion in the dog. Cardiovasc Res. 1994 Jul;28(7):947-56. PubMed PMID: 7954605.
Williams JC, Stein RL, Giles RE, Krell RD. Biochemistry and pharmacology of ICI 200,880, a synthetic peptide inhibitor of human neutrophil elastase. Ann N Y Acad Sci. 1991;624:230-43. PubMed PMID: 2064224.
Davis PC, Wildonger RA, Veale HS. A specific radioimmunoassay for the measurement of ICI 200,880, an elastase inhibitor, in human serum. J Pharm Biomed Anal. 1993 Jul;11(7):549-56. PubMed PMID: 8399528.
Williams JC, Falcone RC, Knee C, Stein RL, Strimpler AM, Reaves B, Giles RE, Krell RD. Biologic characterization of ICI 200,880 and ICI 200,355, novel inhibitors of human neutrophil elastase. Am Rev Respir Dis. 1991 Oct;144(4):875-83. PubMed PMID: 1928965.