Metkephamid acetate
| Code | Size | Price |
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| TAR-T25804L-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25804L-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Metkephamid acetate is a synthetic opioid pentapeptide and derivative of [Met]enkephalin. It shows as a potent agonist of the δ- and u-opioid receptors with roughly equipotent affinity, and also has similarly high affinity as well as subtype-selectivity for the κ3-opioid receptor.
CAS:
66960-35-8
Molecular Weight:
660.79
Purity:
0.98
SMILES:
CC(O)=O.CSCC[C@H](N(C)C(=O)[C@@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(N)=O
References
Burkhardt C, Frederickson RC, Pasternak GW. Metkephamid (Tyr-D-ala-Gly-Phe-N(Me)Met-NH2), a potent opioid peptide: receptor binding and analgesic properties. Peptides. 1982 Sep-Oct;3(5):869-71. PubMed PMID: 6294639.
Pasanisi F, Sloan L, Rubin PC. Cardiovascular properties of metkephamid, a delta opioid receptor agonist, in man. Clin Sci (Lond). 1985 Feb;68(2):209-13. PubMed PMID: 2981652.
Bloomfield SS, Barden TP, Mitchell J. Metkephamid and meperidine analgesia after episiotomy. Clin Pharmacol Ther. 1983 Aug;34(2):240-7. PubMed PMID: 6872419.
Leander JD, Wood CR. Metkephamid effects on operant behavior. Peptides. 1982 Sep-Oct;3(5):771-3. PubMed PMID: 7177922.