Octicidine
| Code | Size | Price |
|---|
| TAR-T25896-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T25896-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Octicidine is derived from phaseolotoxin by the removal of C-terminal dipeptide. It is a transition state analog that irreversibly suppresses ornithine carbamoyltransferase.
CAS:
65370-68-5
Molecular Weight:
291.22
Purity:
0.98
SMILES:
P(NCCC[C@@H](C(O)=O)N)(OS(N)(=O)=O)(=O)O
References
Langley DB, Templeton MD, Fields BA, Mitchell RE, Collyer CA. Mechanism of inactivation of ornithine transcarbamoylase by Ndelta -(N'-Sulfodiaminophosphinyl)-L-ornithine, a true transition state analogue? Crystal structure and implications for catalytic mechanism. J Biol Chem. 2000 Jun 30;275(26):20012-9. Erratum in: J Biol Chem 2000 Sep 29;275(39):30746. PubMed PMID: 10747936.
Templeton MD, Mitchell RE, Sullivan PA, Shepherd MG. The inactivation of ornithine transcarbamoylase by N delta-(N'-sulpho-diaminophosphinyl)-L-ornithine. Biochem J. 1985 Jun 1;228(2):347-52. PubMed PMID: 4015624; PubMed Central PMCID: PMC1144992.
Hatziloukas E, Panopoulos NJ. Origin, structure, and regulation of argK, encoding the phaseolotoxin-resistant ornithine carbamoyltransferase in Pseudomonas syringae pv. phaseolicola, and functional expression of argK in transgenic tobacco. J Bacteriol. 1992 Sep;174(18):5895-909. PubMed PMID: 1522066; PubMed Central PMCID: PMC207126.
Templeton MD, Reinhardt LA, Collyer CA, Mitchell RE, Cleland WW. Kinetic analysis of the L-ornithine transcarbamoylase from Pseudomonas savastanoi pv. phaseolicola that is resistant to the transition state analogue (R)-N delta-(N'-sulfodiaminophosphinyl)-L-ornithine. Biochemistry. 2005 Mar 22;44(11):4408-15. PubMed PMID: 15766270.