Rubradirin
| Code | Size | Price |
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| TAR-T26162-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| TAR-T26162-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Rubradirin is an antibiotic with a complex chemical structure that is active vs. methicillin resistant staphylococci. It is a selective enzymatic peptide initiation inhibitor.
CAS:
11031-38-2
Molecular Weight:
998.904
Purity:
0.98
SMILES:
COC1C(C)OC(CC1(C)N(=O)=O)Oc1cc(nc(C(=O)OC2C(C)C=C(C)C(=O)c3c(O)c(C)cc4C(=O)C5=C(OC(C)(CN5)C(=O)C2O)C(=O)c34)c1O)C(=O)Nc1c(O)c2ccc(OC)cc2oc1=O |w:25.25,t:40|
References
Hoeksema H, Lewis C, Mizsak SA, Shiley JA, Wait DR, Whaley HA, Zurenko GE. The isolation and characterization of rubradirin B. J Antibiot (Tokyo). 1978 Oct;31(10):945-8. PubMed PMID: 711617.
Kim CG, Lamichhane J, Song KI, Nguyen VD, Kim DH, Jeong TS, Kang SH, Kim KW, Maharjan J, Hong YS, Kang JS, Yoo JC, Lee JJ, Oh TJ, Liou K, Sohng JK. Biosynthesis of rubradirin as an ansamycin antibiotic from Streptomyces achromogenes var. rubradiris NRRL3061. Arch Microbiol. 2008 May;189(5):463-73. Epub 2007 Dec 14. PubMed PMID: 18080113.
Bannister B, Zapotocky BA. Protorubradirin, an antibiotic containing a C-nitroso-sugar fragment, is the true secondary metabolite produced by Streptomyces achromogenes var. rubradiris. Rubradirin, described earlier, is its photo-oxidation product. J Antibiot (Tokyo). 1992 Aug;45(8):1313-24. PubMed PMID: 1399853.
Boll B, Heide L. A domain of RubC1 of rubradirin biosynthesis can functionally replace MbtH-like proteins in tyrosine adenylation. Chembiochem. 2013 Jan 2;14(1):43-4. doi: 10.1002/cbic.201200633. Epub 2012 Dec 6. PubMed PMID: 23225745.