Salinamide A
| Code | Size | Price |
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| TAR-T26175-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| TAR-T26175-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Salinamide A is an effective anti-inflammatory bicyclic depsipeptide.
CAS:
152340-22-2
Molecular Weight:
1020.147
Purity:
0.98
SMILES:
[H][C@]12COC(=O)CNC(=O)\C=C/[C@]3(CO3)[C@@H](C)Oc3ccc(cc3)[C@]([H])(NC(=O)[C@]([H])(NC(=O)[C@@H](NC(=O)[C@H](C)[C@H](O)C(C)C)[C@@H](C)OC1=O)[C@@H](C)CC)C(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N[C@]([H])([C@@H](C)O)C(=O)N2 |c:10|
References
Tan L, Ma D. Total synthesis of salinamide A: a potent anti-inflammatory bicyclic depsipeptide. Angew Chem Int Ed Engl. 2008;47(19):3614-7. doi: 10.1002/anie.200800397. PubMed PMID: 18383490.
Degen D, Feng Y, Zhang Y, Ebright KY, Ebright YW, Gigliotti M, Vahedian-Movahed H, Mandal S, Talaue M, Connell N, Arnold E, Fenical W, Ebright RH. Transcription inhibition by the depsipeptide antibiotic salinamide A. Elife. 2014 Apr 30;3:e02451. doi: 10.7554/eLife.02451. PubMed PMID: 24843001; PubMed Central PMCID: PMC4029172.
Ray L, Yamanaka K, Moore BS. A Peptidyl-Transesterifying Type I Thioesterase in Salinamide Biosynthesis. Angew Chem Int Ed Engl. 2016 Jan 4;55(1):364-7. doi: 10.1002/anie.201508576. Epub 2015 Nov 10. PubMed PMID: 26553755; PubMed Central PMCID: PMC4715598.