BI-44370
| Code | Size | Price |
|---|
| TAR-T26796-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T26796-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
BI-44370, a CGRP (calcitonin gene-related peptide) receptor antagonist, can be used to treat migraines and other chronic pain.
CAS:
866086-05-7
Molecular Weight:
633.78
Purity:
0.98
SMILES:
O=C1N(C2CCN(C(O[C@@H](C(=O)N3CCC(CC3)N4CCOCC4)CC5=CC(C)=C(O)C(C)=C5)=O)CC2)CCC=6C(N1)=CC=CC6
References
Negro A, Lionetto L, Simmaco M, Martelletti P. CGRP receptor antagonists: an expanding drug class for acute migraine? Expert Opin Investig Drugs. 2012 Jun;21(6):807-18. doi: 10.1517/13543784.2012.681044. Epub 2012 Apr 19. Review. PubMed PMID: 22512641.
Diener HC, Barbanti P, Dahl?f C, Reuter U, Habeck J, Podhorna J. BI 44370 TA, an oral CGRP antagonist for the treatment of acute migraine attacks: results from a phase II study. Cephalalgia. 2011 Apr;31(5):573-84. doi: 10.1177/0333102410388435. Epub 2010 Dec 20. PubMed PMID: 21172952.
Hougaard A, Tfelt-Hansen P. Review of dose-response curves for acute antimigraine drugs: triptans, 5-HT1F agonists and CGRP antagonists. Expert Opin Drug Metab Toxicol. 2015;11(9):1409-18. doi: 10.1517/17425255.2015.1055244. Epub 2015 Jun 26. Review. PubMed PMID: 26095133.
Palme O, Moszyk A, Iph?fer D, Lang S. Selected microbial glycolipids: production, modification and characterization. Adv Exp Med Biol. 2010;672:185-202. Review. PubMed PMID: 20545283.