TargetMol

LBM-415

Product Code:
 
TAR-T27802
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
LBM-415 is a peptide deformylase (PDF) inhibitor.
CAS:
478913-91-6
Molecular Weight:
396.41
Purity:
0.98
SMILES:
C([C@@H](CN(C=O)O)CCCC)(=O)N1[C@H](C(NC=2N(=O)=CC(F)=CC2)=O)CCC1

References

Yu L, Zhou W, Wang Z. Synthesis and in vitro antibacterial activity of oxazolidine LBM-415 analogs as peptide deformylase inhibitors. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1541-4. doi: 10.1016/j.bmcl.2010.12.097. Epub 2010 Dec 24. PubMed PMID: 21288715. Wang Z, Zhou W. Synthesis and in vitro antibacterial activity of (2S)-N-(substitutedphenyl)-1-[(2R)-2-[(formylhydroxyamino)methyl]-1-oxohexyl]-2-p yrrolidinecarboxamides as potential peptide deformylase inhibitors. Chem Biol Drug Des. 2009 Jan;73(1):142-6. doi: 10.1111/j.1747-0285.2008.00753.x. PubMed PMID: 19152643. Sangshetti JN, Khan FA, Shinde DB. Peptide deformylase: a new target in antibacterial, antimalarial and anticancer drug discovery. Curr Med Chem. 2015;22(2):214-36. Review. PubMed PMID: 25174923. Guay DR. Drug forecast - the peptide deformylase inhibitors as antibacterial agents. Ther Clin Risk Manag. 2007 Aug;3(4):513-25. PubMed PMID: 18472972; PubMed Central PMCID: PMC2374925.