TargetMol

Leucinostatin

Product Code:
 
TAR-T27816
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
Leucinostatin is a peptide mycotoxins that have some potent effects on liver cells after oral administration. Leucinostatin is used as both antimicrobial and antitumor agents through interactions with the membrane phospholipids. Leucinostatin has shown effects against leukemia cell growth and prostate cancer cell growth.
CAS:
39405-64-6
Molecular Weight:
1147.49
Purity:
0.98
SMILES:
CC[C@@H](/C=C/C(N1CC(C[C@H]1C(N[C@H](C(N[C@H](C(NC(C)(C(N[C@H](C(N[C@H](C(NC(C)(C(NC(C)(C(NCCCC(N)=O)=O)C)=O)C)=O)CC(C)C)=O)CC(C)C)=O)C)=O)C(C(C)C)O)=O)CC(CC(CC(CC)=O)O)C)=O)C)=O)C

References

Mikami Y, Fukushima K, Arai T, Abe F, Shibuya H, Ommura Y. Leucinostatins, peptide mycotoxins produced by Paecilomyces lilacinus and their possible roles in fungal infection. Zentralbl Bakteriol Mikrobiol Hyg A. 1984 Jul;257(2):275-83. PubMed PMID: 6485630. Martinez AF, Moraes LA. Liquid chromatography-tandem mass spectrometry characterization of five new leucinostatins produced by Paecilomyces lilacinus CG-189. J Antibiot (Tokyo). 2015 Mar;68(3):178-84. doi: 10.1038/ja.2014.120. Epub 2014 Sep 3. PubMed PMID: 25182486. Fukushima K, Arai T, Mori Y, Tsuboi M, Suzuki M. Studies on peptide antibiotics, leucinostatins. I. Separation, physico-chemical properties and biological activities of leucinostatins A and B. J Antibiot (Tokyo). 1983 Dec;36(12):1606-12. PubMed PMID: 6662804. Wang G, Liu Z, Lin R, Li E, Mao Z, Ling J, Yang Y, Yin WB, Xie B. Biosynthesis of Antibiotic Leucinostatins in Bio-control Fungus Purpureocillium lilacinum and Their Inhibition on Phytophthora Revealed by Genome Mining. PLoS Pathog. 2016 Jul 14;12(7):e1005685. doi: 10.1371/journal.ppat.1005685. eCollection 2016 Jul. PubMed PMID: 27416025; PubMed Central PMCID: PMC4946873.