Corrector C18
| Code | Size | Price |
|---|
| TAR-T31013-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T31013-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Corrector C18 is a class I mutation corrector which rescues CFTR mutations in nucleotide-binding domain 1 (NBD1) by modulating proteostasis.
CAS:
T31013
Molecular Weight:
497.99
Purity:
0.98
SMILES:
O=C(C1(C2=CC(OCO3)=C3C=C2)CC1)NC4=NC=C([C@H](C5=CC=CC=C5Cl)N6C[C@H](O)CC6)S4
References
Chen X, Zhu S, Zhenin M, Xu W, Bose SJ, Wong MP, Leung GPH, Senderowitz H, Chen JH. A defective flexible loop contributes to the processing and gating defects of the predominant cystic fibrosis-causing mutation. FASEB J. 2019 Apr;33(4):5126-5142. doi: 10.1096/fj.201801218RR. Epub 2019 Jan 22. PubMed PMID: 30668920.
Awatade NT, Uliyakina I, Farinha CM, Clarke LA, Mendes K, Sol? A, Pastor J, Ramos MM, Amaral MD. Measurements of Functional Responses in Human Primary Lung Cells as a Basis for Personalized Therapy for Cystic Fibrosis. EBioMedicine. 2014 Dec 17;2(2):147-53. doi: 10.1016/j.ebiom.2014.12.005. eCollection 2015. PubMed PMID: 26137539; PubMed Central PMCID: PMC4484512.
Zeng M, Szymczak M, Ahuja M, Zheng C, Yin H, Swaim W, Chiorini JA, Bridges RJ, Muallem S. Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice. Gastroenterology. 2017 Oct;153(4):1148-1159. doi: 10.1053/j.gastro.2017.06.011. Epub 2017 Jun 19. PubMed PMID: 28634110; PubMed Central PMCID: PMC5623154.
Velard F, Delion M, Lemaire F, Tabary O, Guillaume C, Le Pimpec Barth?s F, Touqui L, Gangloff S, Sermet-Gaudelus I, Jacquot J. Cystic fibrosis bone disease: is the CFTR corrector C18 an option for therapy? Eur Respir J. 2015 Mar;45(3):845-8. doi: 10.1183/09031936.00174014. Epub 2014 Nov 27. PubMed PMID: 25431270.