Doxorubicin-MVCP
| Code | Size | Price |
|---|
| TAR-T31567-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T31567-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Doxorubicin-MVCP (MC-Val-Cit-PAB-Doxorubicin) is a Doxorubicin derivative with an MC-Val-Cit-PAB linker.
CAS:
T31567
Molecular Weight:
1142.18
Purity:
0.98
SMILES:
O=C1C=CC(N1CCCCCC(N[C@@H](C(C)C)C(N[C@H](C(NC(C=C2)=CC=C2COC(N[C@@H](C[C@H](O[C@H]3C[C@@](C(CO)=O)(O)CC4=C(O)C(C(C5=CC=CC(OC)=C5C6=O)=O)=C6C(O)=C43)O7)[C@H](O)[C@@H]7C)=O)=O)CCCNC(N)=O)=O)=O)=O
References
Lin W, Xie X, Deng J, Liu H, Chen Y, Fu X, Liu H, Yang Y. Cell-penetrating peptide-doxorubicin conjugate loaded NGR-modified nanobubbles for ultrasound triggered drug delivery. J Drug Target. 2016 Feb;24(2):134-46. doi: 10.3109/1061186X.2015.1058802. Epub 2015 Jul 15. PubMed PMID: 26176270.
Mizusako H, Tagami T, Hattori K, Ozeki T. Active Drug Targeting of a Folate-Based Cyclodextrin-Doxorubicin Conjugate and the Cytotoxic Effect on Drug-Resistant Mammary Tumor Cells In Vitro. J Pharm Sci. 2015 Sep;104(9):2934-40. doi: 10.1002/jps.24428. Epub 2015 May 4. PubMed PMID: 25940848.
Chung SW, Lee BS, Choi Ju, Kim SW, Kim IS, Kim SY, Byun Y. Optimization of a Stable Linker Involved DEVD Peptide-Doxorubicin Conjugate That Is Activated upon Radiation-Induced Caspase-3-Mediated Apoptosis. J Med Chem. 2015 Aug 27;58(16):6435-47. doi: 10.1021/acs.jmedchem.5b00420. Epub 2015 Aug 18. PubMed PMID: 26263187.
Yu Q, Wei Z, Shi J, Guan S, Du N, Shen T, Tang H, Jia B, Wang F, Gan Z. Polymer-Doxorubicin Conjugate Micelles Based on Poly(ethylene glycol) and Poly(N-(2-hydroxypropyl) methacrylamide): Effect of Negative Charge and Molecular Weight on Biodistribution and Blood Clearance. Biomacromolecules. 2015 Sep 14;16(9):2645-55. doi: 10.1021/acs.biomac.5b00460. Epub 2015 Aug 4. PubMed PMID: 26133354.