Forasartan
| Code | Size | Price |
|---|
| TAR-T31845-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T31845-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Forasartan is a non - peptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan and angiotensin II compete to bind AT1 receptor subtypes in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction, leading to vasodilation. In addition, antagonism against AT1 in the adrenal gland prevents angiotensin II-induced adrenal cortical synthesis and aldosterone secretion stimulation.
CAS:
145216-43-9
Molecular Weight:
416.52
Purity:
0.98
SMILES:
N1=NNC(=N1)C=2C=CC=CC2C=3N=CC(=CC3)CN4N=C(N=C4CCCC)CCCC
References
Aki Y, Tomohiro A, Nishiyama A, Kiyomoto K, Kimura S, Abe Y. The role of basally synthesized nitric oxide in modulating the renal vasoconstrictor action of angiotensin II. Hypertens Res. 1997 Dec;20(4):251-6. PubMed PMID: 9453259.
McMahon EG, Yang PC, Babler MA, Suleymanov OD, Palomo MA, Olins GM, Cook CS. Effects of SC-52458, an angiotensin AT1 receptor antagonist, in the dog. Am J Hypertens. 1997 Jun;10(6):671-7. PubMed PMID: 9194514.
Usune S, Furukawa T. Effects of SC-52458, a new nonpeptide angiotensin II receptor antagonist, on increase in cytoplasmic Ca2+ concentrations and contraction induced by angiotensin II and K(+)-depolarization in guinea-pig taenia coli. Gen Pharmacol. 1996 Oct;27(7):1179-85. PubMed PMID: 8981065.
Kushiku K, Yamada H, Shibata K, Tokunaga R, Katsuragi T, Furukawa T. Upregulation of immunoreactive angiotensin II release and angiotensinogen mRNA expression by high-frequency preganglionic stimulation at the canine cardiac sympathetic ganglia. Circ Res. 2001 Jan 19;88(1):110-6. PubMed PMID: 11139482.