Fosbretabulin [free base]
| Code | Size | Price |
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| TAR-T31857-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T31857-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Fosbretabulin is a natural cis-stilbene that interferes with cellular tubulin dynamics and selectively destroys tumor blood vessels.
CAS:
222030-63-9
Molecular Weight:
396.33
Purity:
0.98
SMILES:
O=P(O)(OC1=CC(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC)O
References
Madadi NR, Penthala NR, Howk K, Ketkar A, Eoff RL, Borrelli MJ, Crooks PA. Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4. Eur J Med Chem. 2015 Oct 20;103:123-32. doi: 10.1016/j.ejmech.2015.08.041. Epub 2015 Aug 29. PubMed PMID: 26352674; PubMed Central PMCID: PMC4631050.
Mahal K, Biersack B, Caysa H, Schobert R, Mueller T. Combretastatin A-4 derived imidazoles show cytotoxic, antivascular, and antimetastatic effects based on cytoskeletal reorganisation. Invest New Drugs. 2015 Jun;33(3):541-54. doi: 10.1007/s10637-015-0215-9. Epub 2015 Feb 14. PubMed PMID: 25678082.
M?ndez-Callejas GM, Leone S, Tanzarella C, Antoccia A. Combretastatin A-4 induces p53 mitochondrial-relocalisation independent-apoptosis in non-small lung cancer cells. Cell Biol Int. 2014 Mar;38(3):296-308. doi: 10.1002/cbin.10199. Epub 2013 Nov 14. PubMed PMID: 24155061.
Wen Z, Xu J, Wang Z, Qi H, Xu Q, Bai Z, Zhang Q, Bao K, Wu Y, Zhang W. 3-(3,4,5-Trimethoxyphenylselenyl)-1H-indoles and their selenoxides as combretastatin A-4 analogs: microwave-assisted synthesis and biological evaluation. Eur J Med Chem. 2015 Jan 27;90:184-94. doi: 10.1016/j.ejmech.2014.11.024. Epub 2014 Nov 13. PubMed PMID: 25461319.