gamma-tert-Butyl methotrexate
| Code | Size | Price |
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| TAR-T31908-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T31908-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
gamma-tert-Butyl methotrexate is a bioactive chemical.
CAS:
79640-76-9
Molecular Weight:
510.55
Purity:
0.98
SMILES:
NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(OC(C)(C)C)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1
References
Wright JE, Rosowsky A, Cucchi CA, Flatow J, Frei E 3rd. Methotrexate and gamma-tert-butyl methotrexate transport in CEM and CEM/MTX human leukemic lymphoblasts. Biochem Pharmacol. 1993 Sep 1;46(5):871-6. PubMed PMID: 8373437.
Rosowsky A, Freisheim JH, Bader H, Forsch RA, Susten SS, Cucchi CA, Frei E 3rd. Methotrexate analogues. 25. Chemical and biological studies on the gamma-tert-butyl esters of methotrexate and aminopterin. J Med Chem. 1985 May;28(5):660-7. PubMed PMID: 3872941.
Wright JE, Rosowsky A, Waxman DJ, Trites D, Cucchi CA, Flatow J, Frei E 3rd. Metabolism of methotrexate and gamma-tert-butyl methotrexate by human leukemic cells in culture and by hepatic aldehyde oxidase in vitro. Biochem Pharmacol. 1987 Jul 1;36(13):2209-14. PubMed PMID: 2440437.