TargetMol

Govaniadine

Product Code:
 
TAR-T31988
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-T31988-100mg100mgEnquire
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TAR-T31988-500mg500mgEnquire
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This product comes from: United States.
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Further Information

Bioactivity:
Govaniadine is a natural potent inducer of apoptosis in MCF-7 cell lines.
CAS:
T31988
Molecular Weight:
325.36
Purity:
0.98
SMILES:
OC1=C(OC)C=CC2=C1[C@@]3([H])N(CC2)CC4=CC(OCO5)=C5C=C4C3

References

Muhammad N, Shrestha RL, Adhikari A, Wadood A, Khan H, Khan AZ, Maione F, Mascolo N, De Feo V. First evidence of the analgesic activity of govaniadine, an alkaloid isolated from Corydalis govaniana Wall. Nat Prod Res. 2015;29(5):430-7. doi: 10.1080/14786419.2014.951933. Epub 2014 Aug 26. PubMed PMID: 25154594. Sivakumaran N, Samarakoon SR, Adhikari A, Ediriweera MK, Tennekoon KH, Malavige N, Thabrew I, Shrestha RLS. Cytotoxic and Apoptotic Effects of Govaniadine Isolated from Corydalis govaniana Wall. Roots on Human Breast Cancer (MCF-7) Cells. Biomed Res Int. 2018 Jul 24;2018:3171348. doi: 10.1155/2018/3171348. eCollection 2018. PubMed PMID: 30140694; PubMed Central PMCID: PMC6081593. Marques LMM, Callejon DR, Pinto LG, de Campos ML, de Oliveira ARM, Vessecchi R, Adhikari A, Shrestha RLS, Peccinini RG, Lopes NP. Pharmacokinetic properties, in vitro metabolism and plasma protein binding of govaniadine an alkaloid isolated from Corydalis govaniana Wall. J Pharm Biomed Anal. 2016 Nov 30;131:464-472. doi: 10.1016/j.jpba.2016.09.003. Epub 2016 Sep 3. PubMed PMID: 27686399. Horst B, Wanner MJ, Jorgensen SI, Hiemstra H, van Maarseveen JH. Total Synthesis of the Ortho-Hydroxylated Protoberberines (S)-Govaniadine, (S)-Caseamine and (S)-Clarkeanidine via a Solvent-directed Pictet-Spengler reaction. J Org Chem. 2018 Nov 19. doi: 10.1021/acs.joc.8b02378. [Epub ahead of print] PubMed PMID: 30451502; PubMed Central PMCID: PMC6328280.