H 189
| Code | Size | Price |
|---|
| TAR-T32037-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32037-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
H 189 is a decapeptide analog of human renin substrate with statine replacing leucine.
CAS:
90145-64-5
Molecular Weight:
1268.51
Purity:
0.98
SMILES:
C([C@H](CC1=CN=CN1)NC(=O)[C@@H]2CCCN2)(=O)N3[C@H](C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC5=CN=CN5)C(N[C@H]([C@H](CC(N[C@H](C(N[C@H](C(N[C@@H](CC6=CN=CN6)C(N[C@@H](CCCCN)C(O)=O)=O)=O)[C@H](CC)C)=O)C(C)C)=O)O)CC(C)C)=O)=O)=O)CCC3
References
Bailey D, Cooper JB, Veerapandian B, Blundell TL, Atrash B, Jones DM, Szelke M. X-ray-crystallographic studies of complexes of pepstatin A and a statine-containing human renin inhibitor with endothiapepsin. Biochem J. 1993 Jan 15;289 ( Pt 2):363-71. PubMed PMID: 8424781; PubMed Central PMCID: PMC1132176.
Tree M, Atrash B, Donovan B, Gamble J, Hallett A, Hughes M, Jones DM, Leckie B, Lever AF, Morton JJ, et al. New inhibitors of human renin tested in vitro and in vivo in the anaesthetized baboon. J Hypertens. 1983 Dec;1(4):399-403. PubMed PMID: 6398331.
G?mez J, Semo N, Freire E. Structural thermodynamic study of the binding of renin inhibitors to endothiapepsin. Adv Exp Med Biol. 1998;436:325-8. PubMed PMID: 9561236.