ISIR-005
| Code | Size | Price |
|---|
| TAR-T32200-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32200-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
ISIR-005 is a natural stabilizer of the 14-3-3/Gab2 protein-protein interaction (PPI) interface.
CAS:
T32200
Formula:
C30H48O8
Molecular Weight:
536.71
Purity:
0.98
SMILES:
O[C@@H]1[C@@H](O)[C@]2([H])OC(C)(C)OC[C@@]2([H])O[C@@H]1O[C@H]3[C@H](O)[C@H](C)[C@@](CC[C@@H]/4COC)([H])C4=C/[C@]5(C)C3=C(C(C)C)CC5
References
Bier D, Bartel M, Sies K, Halbach S, Higuchi Y, Haranosono Y, Brummer T, Kato N, Ottmann C. Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface. ChemMedChem. 2016 Apr 19;11(8):911-8. doi: 10.1002/cmdc.201500484. Epub 2015 Dec 8. PubMed PMID: 26644359.
Kasukabe T, Honma Y, Okabe-Kado J, Higuchi Y, Kato N, Kumakura S. Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells. Oncol Rep. 2016 Aug;36(2):968-76. doi: 10.3892/or.2016.4867. Epub 2016 Jun 10. PubMed PMID: 27375275.