Leucanicidin
| Code | Size | Price |
|---|
| TAR-T32660-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T32660-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Leucanicidin is a macrolide bacterial metabolite originally isolated from S. halstedii. It is toxic to L. separata fourth instar larvae when used at a concentration of 20 ppm and to H. contortus, T. colubriformis, and O. circumcincta larvae (LD50s = 0.23-0.42 ug/ml).
CAS:
91021-66-8
Molecular Weight:
783.009
Purity:
0.98
SMILES:
[H][C@@]1(OC(=O)\C(OC)=C/C(/C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C\C(C)=C\C=C\[C@@H]1OC)[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2OC)[C@H](C)C(O1)C(C)C |c:7,t:10,20,22,@@:53|
References
Wu C, Medema MH, L?kamp RM, Zhang L, Dorrestein PC, Choi YH, van Wezel GP. Leucanicidin and Endophenasides Result from Methyl-Rhamnosylation by the Same Tailoring Enzymes in Kitasatospora sp. MBT66. ACS Chem Biol. 2016 Feb 19;11(2):478-90. doi: 10.1021/acschembio.5b00801. Epub 2015 Dec 24. PubMed PMID: 26675041.
O'Shea MG, Rickards RW, Rothschild JM, Lacey E. Absolute configurations of macrolide antibiotics of the bafilomycin and leucanicidin groups. J Antibiot (Tokyo). 1997 Dec;50(12):1073-7. PubMed PMID: 9510919.
Lacey E, Gill JH, Power ML, Rickards RW, O'Shea MG, Rothschild JM. Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes. Int J Parasitol. 1995 Mar;25(3):349-57. PubMed PMID: 7601593.