MS611
| Code | Size | Price |
|---|
| TAR-T33512-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T33512-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
MS611 is a BET bromine domain inhibitor that shows high selectivity only for BD in the BRD4 bromine domain.
CAS:
T33512
Molecular Weight:
406.46
Purity:
0.98
SMILES:
O=S(C1=CC=C(/N=N/C2=CC(C)=C(O)C(C)=C2)C=C1)(NC3=CC=C(C#N)C=C3)=O
References
Gacias M, Gerona-Navarro G, Plotnikov AN, Zhang G, Zeng L, Kaur J, Moy G, Rusinova E, Rodriguez Y, Matikainen B, Vincek A, Joshua J, Casaccia P, Zhou MM. Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression. Chem Biol. 2014 Jul 17;21(7):841-854. doi: 10.1016/j.chembiol.2014.05.009. Epub 2014 Jun 19. PubMed PMID: 24954007; PubMed Central PMCID: PMC4104156.
Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain Robert P. Law, Stephen J. Atkinson, Paul Bamborough, Chun-wa Chung, Emmanuel H. Demont, Laurie J. Gordon, Matthew Lindon, Rab K. Prinjha, Allan J. B. Watson, and David J. Hirst Publication Date (Web): April 15, 2018 (Article) doi: 10.1021/acs.jmedchem.7b01666