Jervine HCl
| Code | Size | Price |
|---|
| TAR-T3363L-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3363L-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Jervine is a naturally occurring steroidal alkaloid derived from the Veratrum plant species. Over the Hedgehog signaling pathway, Jervine effectively inhibits tumor growth using three human tumor xenograft models. Jervine has the potential to advance to treatment for different tumors.
CAS:
60326-37-6
Molecular Weight:
553.525
Purity:
0.98
SMILES:
I.[H][C@@]12C[C@H](C)CN[C@@]1([H])[C@@H](C)[C@@]1(CC[C@]3([H])C(C(=O)[C@@]4([H])[C@@]3([H])CC=C3C[C@@H](O)CC[C@]43C)=C1C)O2 |c:36,t:26|
References
Wang L, Yao ZP, Li P, Chen SB, So PK, Shi ZQ, Hu B, Liu LF, Xin GZ. Global detection and semi-quantification of Fritillaria alkaloids in Fritillariae Ussuriensis Bulbus by a non-targeted multiple reaction monitoring approach. J Sep Sci. 2016 Jan;39(2):287-95. doi: 10.1002/jssc.201500880. Epub 2015 Dec 7. PubMed PMID: 26530331.
Park J, Jeon YD, Kim HL, Kim DS, Han YH, Jung Y, Youn DH, Kang J, Yoon D, Jeong MY, Lee JH, Hong SH, Lee J, Um JY. Veratri Nigri Rhizoma et Radix (Veratrum nigrum L.) and Its Constituent Jervine Prevent Adipogenesis via Activation of the LKB1-AMPK?-ACC Axis In Vivo and In Vitro. Evid Based Complement Alternat Med. 2016;2016:8674397. doi: 10.1155/2016/8674397. Epub 2016 Apr 6. PubMed PMID: 27143989; PubMed Central PMCID: PMC4837256.
Bailly B, Richard CA, Sharma G, Wang L, Johansen L, Cao J, Pendharkar V, Sharma DC, Galloux M, Wang Y, Cui R, Zou G, Guillon P, von Itzstein M, El?ou?t JF, Altmeyer R. Targeting human respiratory syncytial virus transcription anti-termination factor M2-1 to inhibit in vivo viral replication. Sci Rep. 2016 May 19;6:25806. doi: 10.1038/srep25806. PubMed PMID: 27194388; PubMed Central PMCID: PMC4872165.
Li Q, Yang KX, Zhao YL, Qin XJ, Yang XW, Liu L, Liu YP, Luo XD. Potent anti-inflammatory and analgesic steroidal alkaloids from Veratrum taliense. J Ethnopharmacol. 2016 Feb 17;179:274-9. doi: 10.1016/j.jep.2015.12.059. Epub 2015 Dec 29. PubMed PMID: 26743225.