Ozolinone
| Code | Size | Price |
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| TAR-T33851-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T33851-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Ozolinone is an active metabolite of etozoline which acts as a loop diuretic --- a diuretic that acts at the ascending limb of the loop of Henle in the kidney. Loop diuretics are primarily used in medicine to treat hypertension and edema often due to congestive heart failure or renal insufficiency.
CAS:
56784-39-5
Formula:
C11H16N2O3S
Molecular Weight:
256.32
Purity:
0.98
SMILES:
O=C1C(S/C(=C\C(O)=O)/N1C)N2CCCCC2
References
Rybak LP, Whitworth C, Scott V. Comparative acute ototoxicity of loop diuretic compounds. Eur Arch Otorhinolaryngol. 1991;248(6):353-7. PubMed PMID: 1930985.
Benabe JE, Pedraza-Chaverri J, Mart?nez-Maldonado M. Mechanisms of ozolinone-induced renin release and diuresis. Am J Hypertens. 1993 Aug;6(8):701-7. PubMed PMID: 8217033.
Barthelmebs M, Stephan D, Fontaine C, Grima M, Imbs JL. Vascular effects of loop diuretics: an in vivo and in vitro study in the rat. Naunyn Schmiedebergs Arch Pharmacol. 1994 Feb;349(2):209-16. PubMed PMID: 8170505.
Barthelmebs M, Stephan D, Krieger JP, Grima M, Imbs JL. Stereoselective renal effects of the loop diuretic ozolinone in the anesthetized dog. Naunyn Schmiedebergs Arch Pharmacol. 1995 Jun;351(6):660-71. PubMed PMID: 7675125.