PBP1
| Code | Size | Price |
|---|
| TAR-T33893-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T33893-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
PBP1 is a selective inducer of i-motif structures from the unstructured single-stranded DNA conformations which upregulates BCL-2 gene expression in cancer cells.
CAS:
T33893
Molecular Weight:
804.92
Purity:
0.98
SMILES:
O=C(C1=NC(C(NCC2=CN(C3=CC=C(NC([C@H]4NCCC4)=O)C=C3)N=N2)=O)=CC(OCCCN(C)C)=C1)NCC5=CN(C6=CC=C(NC([C@H]7NCCC7)=O)C=C6)N=N5
References
Ostrowski LA, Hall AC, Szafranski KJ, Oshidari R, Abraham KJ, Chan JNY, Krustev C, Zhang K, Wang A, Liu Y, Guo R, Mekhail K. Conserved Pbp1/Ataxin-2 regulates retrotransposon activity and connects polyglutamine expansion-driven protein aggregation to lifespan-controlling rDNA repeats. Commun Biol. 2018 Nov 5;1:187. doi: 10.1038/s42003-018-0187-3. eCollection 2018. PubMed PMID: 30417124; PubMed Central PMCID: PMC6218562.
Plata KB, Riosa S, Singh CR, Rosato RR, Rosato AE. Targeting of PBP1 by ?-lactams determines recA/SOS response activation in heterogeneous MRSA clinical strains. PLoS One. 2013 Apr 23;8(4):e61083. doi: 10.1371/journal.pone.0061083. Print 2013. PubMed PMID: 23637786; PubMed Central PMCID: PMC3634065.