PBP2
| Code | Size | Price |
|---|
| TAR-T33894-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T33894-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
PBP2 is a selective inducer of G-quadruplex structures from the unstructured single-stranded DNA conformations. PBP2 downregulates BCL-2 gene expression in cancer cells.
CAS:
T33894
Molecular Weight:
804.92
Purity:
0.98
SMILES:
O=C(C1=NC(C(NCC2=CN(C3=CC=CC(NC([C@H]4NCCC4)=O)=C3)N=N2)=O)=CC(OCCCN(C)C)=C1)NCC5=CN(C6=CC=CC(NC([C@H]7NCCC7)=O)=C6)N=N5
References
Thakur SD, Levett PN, Horsman GB, Dillon JR. Association of Neisseria gonorrhoeae genogroups and specific PBP2/MtrR/PorB mutation patterns with susceptibility to penicillin in a susceptible gonococcal population. J Antimicrob Chemother. 2018 Oct 1;73(10):2682-2686. doi: 10.1093/jac/dky233. PubMed PMID: 29992304.
Rohs PDA, Buss J, Sim SI, Squyres GR, Srisuknimit V, Smith M, Cho H, Sjodt M, Kruse AC, Garner EC, Walker S, Kahne DE, Bernhardt TG. A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery. PLoS Genet. 2018 Oct 18;14(10):e1007726. doi: 10.1371/journal.pgen.1007726. eCollection 2018 Oct. PubMed PMID: 30335755; PubMed Central PMCID: PMC6207328.
?br?k M, L?z?r A, Sz?cs?nyi M, De?k J, Urb?n E. Combination of MALDI-TOF MS and PBP2' latex agglutination assay for rapid MRSA detection. J Microbiol Methods. 2018 Jan;144:122-124. doi: 10.1016/j.mimet.2017.11.021. Epub 2017 Nov 24. PubMed PMID: 29180272.
Lange F, Pfennigwerth N, H?fken LM, Gatermann SG, Kaase M. Characterization of mutations in Escherichia coli PBP2 leading to increased carbapenem MICs. J Antimicrob Chemother. 2018 Nov 27. doi: 10.1093/jac/dky476. [Epub ahead of print] PubMed PMID: 30496417.