Simaomicin alpha
| Code | Size | Price |
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| TAR-T34643-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T34643-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Simaomicin alpha is an actinomycete metabolite isolated from an actinomycete strain.
CAS:
100157-22-0
Molecular Weight:
535.505
Purity:
0.98
SMILES:
[H][C@@]12Cc3c(OC)c4oc5[C@@H](O)CC[C@H](O)c5c(=O)c4c(O)c3-c3c(O)c4c(cc(C)n(C)c4=O)c(OCO1)c23
References
Koizumi Y, Tomoda H, Kumagai A, Zhou XP, Koyota S, Sugiyama T. Simaomicin ?, a polycyclic xanthone, induces G? arrest with suppression of retinoblastoma protein phosphorylation. Cancer Sci. 2009 Feb;100(2):322-6. doi: 10.1111/j.1349-7006.2008.01033.x. PubMed PMID: 19077005.
Maiese WM, Korshalla J, Goodman J, Torrey MJ, Kantor S, Labeda DP, Greenstein M. Simaomicin (LL-D42067), a novel antibiotic from Actinomadura madurae. I. Taxonomy, fermentation and biological activity. J Antibiot (Tokyo). 1990 Sep;43(9):1059-63. PubMed PMID: 2211367.
Arai M, Sato H, Kobayashi H, Suganuma M, Kawabe T, Tomoda H, Omura S. Selective inhibition of bleomycin-induced G2 cell cycle checkpoint by simaomicin alpha. Biochem Biophys Res Commun. 2004 May 7;317(3):817-22. PubMed PMID: 15081413.
Ishiyama A, Otoguro K, Namatame M, Nishihara A, Furusawa T, Takahashi Y, Masuma R, Shiomi K, Omura S. Simaomicin alpha: effects on the cell cycle of synchronized, cultured Plasmodium falciparum. J Antibiot (Tokyo). 2008 Apr;61(4):254-7. doi: 10.1038/ja.2008.38. PubMed PMID: 18503207.