Zaragozic acid B
| Code | Size | Price |
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| TAR-T35295-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T35295-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Zaragozic acid B is a fungal metabolite.
CAS:
146389-61-9
Molecular Weight:
730.848
Purity:
0.98
SMILES:
CC=CCCCCC=CCCCCC(=O)OC1C(O)C2(CCC(C)C(O)C(C)CC=Cc3ccccc3)OC1(C(O)=O)C(O)(C(O2)C(O)=O)C(O)=O |w:8.8,1.0,29.28,TLB:46:44:37:16.17,18:17:37:44.45.42,THB:15:16:37:44.45.42,43:42:37:16.17,49:42:37:16.17|
References
Bergstrom JD, Dufresne C, Bills GF, Nallin-Omstead M, Byrne K. Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase. Annu Rev Microbiol. 1995;49:607-39. Review. PubMed PMID: 8561474.
Alaei P, MacNulty EE, Ryder NS. Inhibition of protein prenylation down-regulates signalling by inflammatory mediators in human keratinocytes. Biochem Biophys Res Commun. 1996 May 6;222(1):133-8. PubMed PMID: 8630058.
Hornby JM, Nickerson KW. Enhanced production of farnesol by Candida albicans treated with four azoles. Antimicrob Agents Chemother. 2004 Jun;48(6):2305-7. PubMed PMID: 15155241; PubMed Central PMCID: PMC415631.
Hornby JM, Kebaara BW, Nickerson KW. Farnesol biosynthesis in Candida albicans: cellular response to sterol inhibition by zaragozic acid B. Antimicrob Agents Chemother. 2003 Jul;47(7):2366-9. PubMed PMID: 12821501; PubMed Central PMCID: PMC161837.