Zaragozic acid E
| Code | Size | Price |
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| TAR-T35296-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T35296-500mg | 500mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
Zaragozic acid E is a fungal metabolite.
CAS:
151990-70-4
Molecular Weight:
722.828
Purity:
0.98
SMILES:
CC(CCCc1ccccc1)C=CCCC(=O)OC1C(O)C2(CCC=CC(C)CCCc3ccccc3)OC1(C(O)=O)C(O)(C(O2)C(O)=O)C(O)=O |w:12.13,24.24,TLB:46:44:37:18.19,20:19:37:44.45.42,THB:17:18:37:44.45.42,43:42:37:18.19,49:42:37:18.19|
References
Lanterna C, Musumeci A, Raccosta L, Corna G, Moresco M, Maggioni D, Fontana R, Doglioni C, Bordignon C, Traversari C, Russo V. The administration of drugs inhibiting cholesterol/oxysterol synthesis is safe and increases the efficacy of immunotherapeutic regimens in tumor-bearing mice. Cancer Immunol Immunother. 2016 Nov;65(11):1303-1315. Epub 2016 Aug 12. PubMed PMID: 27520505.
Liu N, Hung YS, Gao SS, Hang L, Zou Y, Chooi YH, Tang Y. Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway. Org Lett. 2017 Jul 7;19(13):3560-3563. doi: 10.1021/acs.orglett.7b01534. Epub 2017 Jun 13. PubMed PMID: 28605916; PubMed Central PMCID: PMC5673471.
McHale-Owen H, Bate C. Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-? oligomers. Biochim Biophys Acta. 2018 Mar;1864(3):649-659. doi: 10.1016/j.bbadis.2017.12.017. Epub 2017 Dec 13. PubMed PMID: 29247837.
Liddle E, Scott A, Han LC, Ivison D, Simpson TJ, Willis CL, Cox RJ. In vitro kinetic study of the squalestatin tetraketide synthase dehydratase reveals the stereochemical course of a fungal highly reducing polyketide synthase. Chem Commun (Camb). 2017 Feb 4;53(10):1727-1730. doi: 10.1039/c6cc10172k. Epub 2017 Jan 20. PubMed PMID: 28106181.