(S,R,S)-AHPC-C6-NH2 dihydrochloride
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20°C
Documents
Further Information
Bioactivity:
(S,R,S)-AHPC-C6-NH2 dihydrochloride (also known as VH032-C6-NH2 dihydrochloride) is a synthesized compound that functions as a ligand-linker conjugate for E3 ligase. It incorporates the VH032-based VHL ligand along with a linker, which is used for the degradation of AKT PROTAC. This compound, also referred to as XF038-161A or example 6, was extracted from patent WO2019173516A1.
CAS:
2341796-77-6
Molecular Weight:
594.21
Purity:
0.98
SMILES:
C([C@@H](NC(CCCCCCN)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1.Cl.Cl
References
Jian Jin, et al. Serine threonine kinase (akt) degradation / disruption compounds and methods of use. Patent WO2019173516A1.