TargetMol

TLR7/8 agonist 4 hydroxy-PEG10-acid

Product Code:
 
TAR-T39968
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
TLR7/8 agonist 4 hydroxy-PEG10-acid (compound 9) is a drug-linker conjugate employed in antibody-drug conjugates (ADC). This compound exhibits remarkable antitumor activity by utilizing TLR7/8 agonist 4, which acts as a potent activator of TLR7/8. The TLR7/8 agonist 4 is linked to hydroxy-PEG10-acid, the ADC linker, via a cleavable bond. Overall, it demonstrates promising pharmaceutical potential in the context of ADC-based therapeutics.
CAS:
2388520-17-8
Molecular Weight:
837.025
Purity:
0.98
SMILES:
CCCCc1nc2c(N)nc3ccc(cc3c2[nH]1)N1CCN(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)CC1

References

Shelley Erin ACKERMAN, et al. Immunoconjugates targeting her2. WO2020190725A1.