TargetMol

PROTAC IRAK3 degrade-1

Product Code:
 
TAR-T40334
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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Further Information

Bioactivity:
PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 ( IC 50 = 5 nM).
CAS:
2712600-00-3
Molecular Weight:
878.092
Purity:
0.98
SMILES:
CC(C)c1ccn2ncnc(N[C@H]3CC[C@H](CC3)N3CCN(CC3)C(=O)CCC(=O)N3CCC(CCN4CCN(CC4)c4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)c12 |wU:15.18,12.11,(-.91,-3.09,;-1.94,-1.94,;-3.45,-2.26,;-1.46,-.48,;-2.37,.77,;-1.46,2.02,;,1.54,;1.33,2.31,;2.67,1.54,;2.67,,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;5.33,-4.62,;4,-5.39,;2.67,-4.62,;6.67,-5.39,;6.67,-6.93,;8,-7.7,;9.34,-6.93,;9.34,-5.39,;8,-4.62,;10.67,-7.7,;10.67,-9.24,;12,-6.93,;13.34,-7.7,;14.67,-6.93,;14.67,-5.39,;16,-7.7,;16,-9.24,;17.34,-10.01,;18.67,-9.24,;20.01,-10.01,;21.34,-9.24,;22.67,-10.01,;22.67,-11.55,;24.01,-12.32,;25.34,-11.55,;25.34,-10.01,;24.01,-9.24,;26.67,-12.32,;26.67,-13.86,;28.01,-14.63,;29.34,-13.86,;30.81,-14.34,;31.28,-15.8,;31.71,-13.09,;33.25,-13.09,;34.02,-14.42,;35.56,-14.42,;36.33,-13.09,;37.87,-13.09,;35.56,-11.76,;34.02,-11.76,;33.25,-10.42,;30.81,-11.84,;31.28,-10.38,;29.34,-12.32,;28.01,-11.55,;18.67,-7.7,;17.34,-6.93,;)|

References

Degorce SL, et al. Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase. J Med Chem. 2020 Sep 24;63(18):10460-10473.